The effect of minimal-flow and high-flow hypotensive anesthesia on oxidative stress

Objective: The main objective of this study was to compare the effects minimal and high gas flow-controlled hypotension applications on IMA thiol/disulfide balance, which are indicators oxidative stress.Methods: Patients undergoing elective tympanoplasty were randomized two groups as minimal-flow high-flow anesthesia groups. Minimal flow performed with 5L/min fresh reduced 0.4 L/min. High administered 2 L/min gas. Preoperative intraoperative SpO2, StO2, EtCO2, mean arterial pressure heart rate values recorded. IMA, total thiol, native disulfide, disulfide/native thiol disulfide/total recorded compared between Results: statistically notably higher in group (p=0.048). SPO2 value remarkably (p=0.032). EtCO2 lower at 5 minutes 15 operation (p=0.029; p=0.048). preoperative (for both, p=0.001). There no remarkable difference terms other monitored parameters all, p>0.05).Conclusion: found be significantly anesthesia. However, notable homeostasis, indicating need for further comprehensive studies order draw a definitive conclusion